3'UTR-derived small RNA couples acid resistance to metabolic reprogramming of Salmonella within macrophages
Takeshi Kanda, Fang Liu, Hoda Kooshapour, Sarah Reichardt, Maolin Wang, Philippe Icyishaka, Nozomu Obana, Alexander J. Westermann, Yanjie Chao, Masatoshi Miyakoshi
This study identifies AdiZ, a small RNA derived from the 3'UTR of adiA mRNA in Salmonella, which regulates metabolic genes and promotes survival in macrophage vacuoles under acidic and hypoxic conditions.
Nucleic Acids Research · Nov 19, 2025Peer-reviewedMicrobiology