Genetic Determinants Underlying the Progressive Phenotype of Beta-lactam/Beta-lactamase Inhibitor Resistance in Escherichia coli
William C. Shropshire, Hatim Amiji, Jordan Bremer, Selvalakshmi Selvaraj Anand, Benjamin Strope, Pranoti V. Sahasrabhojane, Marc Gohel, Samuel L Aitken, Sarah L. Spitznogle, Xiaowei Zhan, Jiwoong Kim, David E. Greenberg, Samuel A. Shelburne
The paper analyzes WGS data of E. coli isolates to show that blaTEM gene amplification correlates with resistance to AMC and TZP but not SAM, highlighting the need for comprehensive analysis of genetic determinants in BL/BLI resistance.
Microbiology Spectrum · Oct 6, 2023Peer-reviewedGenomics