Author

William C. Shropshire

The University of Texas MD Anderson Cancer CenterORCID 0000-0001-8556-3248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 4 Approach:statistical model· 3 Organism:E. coli· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Micah M. BhattiiD· 3 shared Pranoti V. Sahasrabhojane· 3 shared Samuel A. ShelburneiD· 3 shared Samuel L AitkeniD· 3 shared Anna KonovalovaiD· 2 shared Awdhesh KaliaiD· 2 shared Benjamin Strope· 2 shared Blake HansoniD· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenomics

Micah M. BhattiORCID

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4 papers

Recent·Most cited

MicrobiologyThe Journal of Infectious DiseasesPeer-reviewedNov 27, 2024

Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure

William C. Shropshire, Xinhao Song, Jordan Bremer…·Samuel A. Shelburne

The paper assesses how ESBL-positive ST131 E. coli adapts to carbapenem exposure, finding increased ESBL gene copy numbers and Omp gene mutations correlate with resistance development.

4 citations

E. coliwhole-genome sequencing

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GenomicsMicrobiology SpectrumPeer-reviewedOct 6, 2023

Genetic Determinants Underlying the Progressive Phenotype of Beta-lactam/Beta-lactamase Inhibitor Resistance in Escherichia coli

William C. Shropshire, Hatim Amiji, Jordan Bremer…·Samuel A. Shelburne

The paper analyzes WGS data of E. coli isolates to show that blaTEM gene amplification correlates with resistance to AMC and TZP but not SAM, highlighting the need for comprehensive analysis of genetic determinants in BL/BLI resistance.

7 citations

E. coliwhole-genome sequencing

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GenomicsbioRxivPreprintMay 20, 2022

Systematic Analysis of Mobile Genetic Elements Mediating β-lactamase Gene Amplification in Non-Carbapenemase-Producing Carbapenem Resistant Enterobacterales Bloodstream Infections

William C. Shropshire, Anna Konovalova, Patrick M. McDaneld…·SA Shelburne

This study identifies mobile genetic elements driving β-lactamase gene amplification in non-CP-CRE bloodstream infections through genomic analysis.

DOI 10.1101/2022.05.20.492874

humanwhole-genome sequencing

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GenomicsJournal of Antimicrobial ChemotherapyPeer-reviewedOct 8, 2020

Concurrence of Porin Loss and Modular Amplification of β-Lactamase Encoding Genes Drives Carbapenem Resistance in a Cohort of Recurrent Enterobacterales Bacteremia

William C. Shropshire, Samuel L Aitken, Reed Pifer…·Samuel A. Shelburne

This study identifies non-carbapenemase-producing CRE mechanisms in recurrent Enterobacterales infections driven by porin loss and β-lactamase gene amplification.

59 citations

humanwhole-genome sequencing

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