Differential regulation of KCC2 function, trafficking, and degradation by Ca2+-dependent signaling pathways
Marc J. Bergeron, Isabel Plasencia-Fernández, Annie Barbeau, Noémie Comeau, Martin Cottet, Antoine G. Godin, Yves De Koninck
This study shows that BDNF-TrkB and NMDAR signaling pathways synergistically regulate KCC2 function, trafficking, and degradation through distinct Ca2+-dependent mechanisms.
bioRxiv · Jul 3, 2026 · PreprintNeuroscience