Yves De Koninck

Superficial spinal Tac1-lineage neurons are polymodal nociceptive

This study characterizes the developmental and functional diversity of Tac1-lineage neurons in the spinal dorsal horn, showing they are polymodal nociceptive in adults.

Spinotrode: long-term intraspinal electrophysiological recordings to unravel dorsal horn neuron dynamics in behaving mice

The paper introduces Spinotrode, a vertebral implant for long-term single-cell recordings in the dorsal horns of behaving mice, revealing new insights into spinal neuron dynamics during natural behaviors.

Multimodal transcriptomics and calcium imaging reveal a novel subset of polymodal nociceptors expressing the interleukin 1 receptor in mice

The paper identifies a novel subset of IL-1R1+ nociceptors in mice using multimodal transcriptomics and calcium imaging, revealing their role in inflammatory pain.

Differential regulation of KCC2 function, trafficking, and degradation by Ca2+-dependent signaling pathways

This study shows that BDNF-TrkB and NMDAR signaling pathways synergistically regulate KCC2 function, trafficking, and degradation through distinct Ca2+-dependent mechanisms.

A neuronal pathway for the supraspinal relay of warm and cool sensation

The paper identifies a neuronal pathway in mice for relaying warm and cool sensations through the anterolateral tract, showing that specific neurons are tuned to innocuous temperature changes.

Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer's disease-like pathology

The paper shows that sustained neuronal hyperactivity in wild-type and AD-like mice leads to proteomic changes similar to AD pathology, including memory loss and increased Aβ42 secretion.

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use

Gut microbiota promotes pain in fibromyalgia

This study shows that gut microbiota from fibromyalgia patients causes pain in mice, and transferring healthy microbiota alleviates symptoms in humans.

Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

The paper identifies a unique cardiac neuronal population expressing calbindin-D28k with distinct electrophysiological properties linked to arrhythmia susceptibility and cardiac pathologies.

Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in mice

This study shows that NRM serotonergic neurons bidirectionally control spinal nociception through different 5-HT receptors, with 5-HT2c mediating analgesia and 5-HT3 causing hyperalgesia.

Thermal and mechanical modalities converge in the noxious range

The paper investigates how sensory fibers encode thermal and mechanical nociceptive input in mice, finding that modality separation dominates in the innocuous range while polymodality predominates in the noxious range.

Assessing spontaneous sensory neuron activity using in vivo calcium imaging

This paper assesses spontaneous sensory neuron activity using in vivo calcium imaging and develops a machine learning algorithm to predict spontaneous activity with high accuracy across different pain models and labs.

Chronic pain mediated changes in the appetitive value of affective touch in mice

This study investigates how chronic pain alters the rewarding value of gentle touch in mice by examining neural circuits and behavioral responses.

KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease

This study identifies KCC2 as an early biomarker and therapeutic target for ALS by showing its downregulation in motor neurons and the ability of KCC2-enhancing compounds to delay disease progression.

A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models

This study investigates the sex-specific role of CGRP in pain models, finding that CGRP promotes pain plasticity in female mice but has limited impact in males.

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

The paper identifies a sex-specific neuronal mechanism of spinal hyperexcitability in pain models, showing differences in BDNF signaling between male and female rodents and humans.

Native KCC2 Interactome Reveals PACSIN1 As A Critical Regulator Of Synaptic Inhibition

The paper identifies PACSIN1 as a key negative regulator of KCC2 function through a native KCC2 interactome analysis in the mouse brain.