A Patient-Derived Ex Vivo Tissue Model of Cholangiocarcinoma Using Precision-Cut Tissue Slices
Timothy M. Gilbert, Owen McGreevy, Maria-Danae Jessel, Roz Jenkins, Mohamed Bosakhar, Marc Quinn, Lawrence O’Leary, Anthony Glyn Evans, Timothy Andrews, Rafael Díaz-Nieto, Robert M. Jones, Stephen William Fenwick, William Greenhalf, Daniel Palmer, Hassan Z. Malik, , Laura E. Randle
This study develops a patient-derived ex vivo cholangiocarcinoma model using precision-cut tissue slices, showing sustained viability, tumour architecture, and pharmacological responsiveness over 15 days.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology