15-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during aging
Rahul Chaudhary, Brittany A. Cordova, Marcus Hong, Bailey R. Klein, Lyannah A. Contreras, Ritisha Rashmil, Filip Goshevski, Julianne N. P. Smith, Derek J. Taylor, Andrew A. Pieper, Sanford D. Markowitz, Amar B. Desai
This study shows that inhibiting 15-PGDH improves hematopoietic stem cell function and recovery in aged mice without affecting normal blood production.
bioRxiv · Apr 11, 2025 · PreprintImmunology