Derek J. Taylor

This study identifies PSMC2 overexpression as a driver of bortezomib resistance in multiple myeloma and shows that combining p97 inhibition with bortezomib overcomes this resistance.

This paper develops multivalent nanobodies that neutralize multiple S. aureus toxins, showing potent activity in murine models of sepsis and pneumonia.

The paper investigates the cellular response to puromycin-induced translation stress and identifies ribosome dimerization mediated by rRNA expansion segments as a conserved stress response mechanism.

The paper determines cryo-EM structures of PP2A-B55 and Eya3 interaction, showing how a peptide inhibitor disrupts this interaction and affects Myc stability in TNBC.

This study shows that inhibiting 15-PGDH improves hematopoietic stem cell function and recovery in aged mice without affecting normal blood production.

The paper presents an integrated model of the vertebrate augmin complex using cryo-EM, structural prediction, and electron microscopy, revealing its structure, conservation, and microtubule binding site.