Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions
Alasdair D. Keith, Ting Xu, Tatiana Alexandrovna Chernova, Meredith M. Keen, Marek Bogacz, Marko Nedeljković, Maria W. Flowers, Trenton J Brown, Filipp Frank, Eric A. Ortlund, Eric J. Sundberg
The paper maps the affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions by analyzing amino acid variations and their effects on binding and effector functions.
bioRxiv · Mar 28, 2025 · PreprintBiochemistry