Eric A. Ortlund

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

This study evaluates antibody responses after a KP.2 spike mRNA vaccine dose, showing durable and broadly cross-reactive immunity against multiple SARS-CoV-2 variants, but reduced neutralizing activity against some emerging subvariants.

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

This study examines how endurance exercise affects liver metabolism in male and female rats over time, revealing sex-specific molecular changes and protective effects.

The paper maps the affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions by analyzing amino acid variations and their effects on binding and effector functions.

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

This study stabilizes an HIV-1 clade C trimer using multiple platforms and shows improved antigenic and immunogenic properties.

The paper describes the engineering of synthetic multivalent VHH antibodies against SARS-CoV-2 spike protein and shows how mutations affect their binding.

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

This study shows that deleting Them2 in skeletal muscle reduces weight gain and improves glucose homeostasis on a high-fat diet, but does not prevent hepatic steatosis.

The paper identifies genetic variants in RGS14 that disrupt nuclear shuttling and impair LTP regulation in hippocampal neurons, with variant LR causing nuclear accumulation and loss of function.

The paper shows that a single gene within a supergene contributes to aggressive behavior in white-throated sparrows through allelic imbalance and regulatory variation.

The paper uses computational methods to analyze how ligand activation and evolutionary mutations affect allosteric networks in an ancestral steroid receptor, identifying key residues that modulate ligand specificity.