Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer Disease
Margaret Bell, Mariame Selma Kane, Xiaosen Ouyang, Martin Elliot Young, Anil Goud Jegga, John C. Chatham, Victor M. Darley-Usmar, Jianhua Zhang
This study examines the acute effects of increasing protein O-GlcNAcylation in mice brains using OGA inhibitor Thiamet G, identifying transcriptome changes opposite to those seen in Alzheimer's disease.
bioRxiv · Sep 19, 2024 · PreprintNeuroscience