Jianhua Zhang

ROCK inhibitor Ripasudil reduces Alzheimer pathological proteins and enhances cellular bioenergetics

This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

Regulation of lipid dysmetabolism and neuroinflammation progression linked with Alzheimer's disease through modulation of Dgat2

This study identifies Dgat2 as a key modulator linking amyloid pathology, lipid dysregulation, and neuroinflammation in Alzheimer's disease across Drosophila and mouse models.

Impact of O-GlcNAcylation elevation on mitophagy and glia in the dentate gyrus

This study shows that elevated O-GlcNAcylation reduces mitophagy in astrocytes and alters glia homeostasis in the dentate gyrus.

Lysosomal cathepsin D regulates bone turnover through distinct mode of actions of the autophagy pathways in osteoblasts and osteoclasts

This study shows that CtsD regulates bone turnover through distinct autophagy mechanisms in osteoblasts and osteoclasts, suggesting it as a therapeutic target for bone mass maintenance.

Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed

This study finds that aging baboons show sex-specific declines in prefrontal cortex mitochondrial bioenergetics, with males experiencing greater ETC activity loss and a link between walking speed and respiration in males.

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer Disease

This study examines the acute effects of increasing protein O-GlcNAcylation in mice brains using OGA inhibitor Thiamet G, identifying transcriptome changes opposite to those seen in Alzheimer's disease.

Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice

This study investigates whether enhancing cathepsin D or disrupting ZKSCAN3 in the CNS can reduce α-synuclein aggregation and dopaminergic neurodegeneration, but finds no significant effect.