Tyrosine phosphorylation and the inhibitory C-terminal SAM domain moderately affect transient interactions in a EphA2 cytoplasmic fragment in solution: A combined experimental and molecular modeling study.
Pravesh Shrestha, Amita Rani Sahoo, Maria Iannucci, Belinda B. Willard, Matthias Buck
This study investigates the structural dynamics of the EphA2 intracellular fragment, showing phosphorylation affects transient interactions and signaling potential.
bioRxiv · Sep 29, 2025 · PreprintBiophysics