Belinda B. Willard

This study challenges the role of MCL1 in chemoresistance by showing no evidence of nuclear accumulation or DNA repair interactions in live cancer cells.

The paper identifies BCL-XL dependence as a common vulnerability in various kidney cancer subtypes and develops a model to predict it using biomarkers like AMPK activation.

The paper shows that inhibiting KDELR2 in tumor cells promotes tumor regression through innate immune activation, independent of T cells, and primes anti-tumor T cells for future challenges.

The paper uses forward and reverse degradomics to analyze proteolytic landscapes in aortic aneurysms, identifying key proteases like MMP9 and CMA1 and their roles in extracellular matrix remodeling.

This study identifies N-acyl amides from gut microbes as regulators of postprandial metabolic homeostasis by affecting host hormones, gene expression, and microbiome composition.

This study investigates how dietary fatty acids interact with gut microbiota and host metabolism to influence lipid homeostasis and cardiometabolic disease in mice.

This study investigates the structural dynamics of the EphA2 intracellular fragment, showing phosphorylation affects transient interactions and signaling potential.

This study identifies that TLR9 activation requires phosphorylation of two specific tyrosine residues by EGFR and Syk, which is critical for downstream signaling.

This paper identifies PML1 as a driver of endocrine resistance in ER+ breast cancer by forming a feedforward loop with PI3K and MAPK pathways, and shows that arsenic trioxide can disrupt this loop.

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

This study shows that carbapenem exposure leads to concentration- and carbapenem-dependent trends in β-lactamase-isoform expression in Acinetobacter baumannii, suggesting non-stochastic resistance mechanisms.

The paper uses proximity labeling to identify Pef1's role in DNA damage response and autophagy-related processes in S. pombe.

This study shows that K6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A, reducing cytokine secretion in corneal epithelial cells.

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.