Biological foundation models illuminate annotation blind spots in evolutionarily divergent genomes
Toby B. Lanser, Sydney K. Caldwell, Gaspar A. Pacheco, Jessica W. Chen, Shahab Saghaei, Mariah Hassan, Meydan Kronrod, Duane R. Wesemann, Hildreth Robert Frost
The paper introduces a hybrid annotation framework that improves cross-species protein similarity assignment and gene annotation in evolutionarily divergent genomes, expanding structural catalogs and improving single-cell immune cell state annotation in sea lamprey.
bioRxiv · May 16, 2026 · PreprintBioinformatics