Shahab Saghaei

The paper identifies tissue Th2 progenitors as a distinct cellular state that sustains chronic type 2 inflammation by self-renewal and effector differentiation.

The paper introduces a hybrid annotation framework that improves cross-species protein similarity assignment and gene annotation in evolutionarily divergent genomes, expanding structural catalogs and improving single-cell immune cell state annotation in sea lamprey.

The paper investigates how antibody affinity maturation and light-chain pairing contribute to neutralizing evolved SARS-CoV-2 variants, identifying mechanisms that enable anticipatory immune breadth.

The paper investigates the origins and diversity of human bone marrow plasma cells, identifying distinct functional profiles and sources of IgE-producing cells in peanut allergy.