Duane R. Wesemann

Progenitor T cells drive chronic pulmonary type 2 inflammation

The paper identifies tissue Th2 progenitors as a distinct cellular state that sustains chronic type 2 inflammation by self-renewal and effector differentiation.

Biological foundation models illuminate annotation blind spots in evolutionarily divergent genomes

The paper introduces a hybrid annotation framework that improves cross-species protein similarity assignment and gene annotation in evolutionarily divergent genomes, expanding structural catalogs and improving single-cell immune cell state annotation in sea lamprey.

Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution

The paper investigates how antibody affinity maturation and light-chain pairing contribute to neutralizing evolved SARS-CoV-2 variants, identifying mechanisms that enable anticipatory immune breadth.

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection

Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody

The paper identifies clonotype-enriched mutations in the light chain of a public antibody that enhance affinity for a conserved viral epitope and increase after repeated vaccinations.

Origins and diversity of pan-isotype human bone marrow plasma cells

The paper investigates the origins and diversity of human bone marrow plasma cells, identifying distinct functional profiles and sources of IgE-producing cells in peanut allergy.

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.