Identification and Credentialing of Patient Derived Xenograft Models of Invasive Lobular Breast Carcinoma using Multi-omics and Histopathology assessment
Jagmohan Hooda, Jennifer M. Atkinson, Osama Shiraz Shah, Megan E. Yates, Daniel D. Brown, Morgan DeBerry, Stefano Cairo, Paolo Schiavini, Hsiu-Wen Tsai, Marianna Zipeto, Rohit Bhargava, Steffi Oesterreich, Adrian V. Lee
This study identifies and characterizes patient-derived xenograft models of invasive lobular breast carcinoma using multi-omics and histopathology, finding seven ILC PDX models with CDH1 mutations and low CDH1 expression.
bioRxiv · Aug 21, 2025 · PreprintCancer Biology