Stefano Cairo

The paper introduces a PDX platform for pediatric cancers, providing in vivo drug testing models and molecular data to aid in therapy development.

This study identifies and characterizes patient-derived xenograft models of invasive lobular breast carcinoma using multi-omics and histopathology, finding seven ILC PDX models with CDH1 mutations and low CDH1 expression.

This study uses single-cell multiomics to trace clonal and phenotypic dynamics in hepatoblastoma after cisplatin treatment, identifying a plasticity-proliferation axis driven by BIRC5.