Cryptic starter amidation in antibiotic biosynthesis by trans-acyltransferase polyketide synthases
Y N Zhang, Marianne Costa, James A. Duncan, Lona M. Alkhalaf, Gregory L. Challis
The paper reveals a cryptic amidation mechanism in gladiolin biosynthesis involving a trans-acyltransferase, ACP, and asparagine synthetase homolog.
bioRxiv · Apr 24, 2026 · PreprintBiochemistry