Lona M. Alkhalaf

This study characterizes SidG, a GNAT enzyme in Aspergillus fumigatus, revealing its iterative acetylation mechanism for siderophore biosynthesis.

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

This paper develops an esterase-mediated strategy to generate unstable substrates for EpnF, revealing its broad substrate tolerance and catalytic mechanism for epoxyketone synthesis.

The paper reveals a cryptic amidation mechanism in gladiolin biosynthesis involving a trans-acyltransferase, ACP, and asparagine synthetase homolog.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.

This paper identifies and characterizes pellemicin, a spirotetronate with antiviral activity against influenza A and B viruses by inhibiting clathrin-mediated endocytosis.

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.