Marianne Rooman

High-quality thermodynamic data on the stability changes of proteins upon single-site mutations

The paper curates a dataset of experimental thermodynamic data on protein stability changes due to single-site mutations for training and benchmarking in silico prediction methods.

Improved insights into protein thermal stability: from the molecular to the structurome scale

This study uses a multi-scale approach to analyze protein thermal stability, revealing differences in mutational profiles between thermostable and mesostable proteins.

Predicting protein thermal stability changes upon point mutations using statistical potentials: Introducing HoTMuSiC

The paper introduces a computational tool to predict changes in protein thermal stability from mutations, achieving high accuracy with a root mean square deviation of 2.9°C.

A little walk from physical to biological complexity: protein folding and stability

The paper develops thermodynamics-based bioinformatics tools to predict protein stability and thermal resistance, and applies them to study aggregation mechanisms in a disease-causing protein.