An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription.
Briana Branch, Yao Zong YUAN, Mariastella Cascone, Francesco Raimondi, Ramiro Iglesias‐Bartolomé
This study improves a dominant-negative TEAD inhibitor, TEADi, by modifying its binding domains to enhance its ability to block YAP1 and TAZ interactions with TEAD, revealing differences in their displacement mechanisms.
bioRxiv · Oct 3, 2024 · PreprintCell Biology