Ramiro Iglesias‐Bartolomé

This study uses CRISPR/dCas13 to interfere with RNA-RBP interactions, showing that disrupting mRNA localization reduces cancer cell invasiveness and metastasis.

The paper identifies Gs pathway inactivation as an SMO-independent Hedgehog signaling driver in BCC and shows adenosine 2B receptor activation can counteract SMO-driven oncogenesis.

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

This study shows that Net1 mRNA localization at the dermal-epidermal junction influences epithelial tissue organization by regulating RhoA activity and DEJ structure.

This study improves a dominant-negative TEAD inhibitor, TEADi, by modifying its binding domains to enhance its ability to block YAP1 and TAZ interactions with TEAD, revealing differences in their displacement mechanisms.