TCR Signal Strength and Eomes Coordinate CD8⁺ T Cell Fate and Antitumor Immunity in Hepatocellular Carcinoma
Hacene Dreidi, Abdulkader Azouz, Sébastien Denanglaire, Solange Dejolier, Faustine Bouffioux, Marie Le Moine, Soren Temara, Lune Cassart, Muriel Nguyen, Lionel Larbanoix, Stanislas Goriely, Fabienne Andris
This study shows that TCR signal strength and Eomes determine CD8+ T cell fate in HCC, with high-affinity signals promoting antitumor immunity and Eomes driving exhaustion.
bioRxiv · Feb 12, 2026 · PreprintImmunology