Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancer
Martina Markovska, Rodney Alexander Rosalia, Aleksandra Stajkovska, Sanja Mehandziska, Marija Janevska, Ivan Kungulovski, Zan K. Mitrev, Goran Kungulovski
The paper examines genetic aberrations in chromatin modifiers across cancer datasets, finding mutual exclusivity, higher prevalence in certain cancers, and links to mutational burden and immunotherapy response.
bioRxiv · Dec 3, 2019 · PreprintGenetics