Goran Kungulovski

The paper identifies PRC2-binding regions as hotspots of DNA methylation variability in pre-cancer and cancer, showing increased entropy and association with aggressive tumor features.

This study quantifies DNA methylation variability across 16 cancer types and links it to genomic instability, tumor aggressiveness, and poor clinical outcomes.

This study shows that tumors with chromatin regulator mutations have higher mutational burden and better response to immunotherapy.

This study identifies a novel read-out mechanism of UHRF1-TTD binding to H3K4me1-K9me2/3 double marks, showing its role in gene down-regulation and chromatin binding.

The paper examines genetic aberrations in chromatin modifiers across cancer datasets, finding mutual exclusivity, higher prevalence in certain cancers, and links to mutational burden and immunotherapy response.