Development of approaches to overcome the drop in hematocrit when implementing mononuclear phagocyte system cytoblockade in vivo used to prolong the circulation of nanoparticles in the blood
Elizaveta N. Mochalova, Maria Yurchenko, Marina P. Timofeeva, Darina A. Maedi, Petr Ivanovich Nikitin, Maxim P. Nikitin
The paper demonstrates methods to restore hematocrit during MPS-cytoblockade, preserving nanoparticle circulation and tumor targeting without compromising safety.
bioRxiv · May 7, 2026 · PreprintPharmacology & Toxicology