Dysfunctional effector programming in Foxp3-ΔE2 Tregs promotes enhanced CD8+ T cell responses
Kristin N. Weinstein, Zoe H. Bishop, Elya Ali Shamskhou, Finnegan N Barry, Gabriela Verdezoto, Marissa de Leon, Joseph R. Albe, Andrew Koval, Baohua Zhou, Phillip P. Domeier, Michael Y. Gerner, Daniel Campbell, Steven F. Ziegler
This study shows that Foxp3-{Delta}E2 Tregs have impaired suppressive function, leading to enhanced CD8+ T cell responses during inflammation.
bioRxiv · Oct 9, 2026 · PreprintImmunology