Daniel Campbell

Homeostatic fibroblast niche collapse in clinically uninvolved skin marks a pre-fibrotic stage of systemic sclerosis

The paper identifies a pre-fibrotic stage in scleroderma by analyzing spatial transcriptomic changes in clinically uninvolved skin, showing early loss of fibroblast niches and vascular reprogramming.

Establishing an ex vivo platform for molecular profiling of skin structural cells using frozen human skin biopsies

This study establishes a scalable ex vivo platform using frozen human skin biopsies to study inflammatory responses in skin structural cells.

Heterogeneity of HCMV-Specific CD8+ T Cells is Established Early in Infection, Clonally Encoded, and Stable Over Time

The paper tracks CMV-specific CD8+ T cells over time to show that clonal diversity and phenotypes are established early and remain stable during chronic infection.

Dysfunctional effector programming in Foxp3-ΔE2 Tregs promotes enhanced CD8+ T cell responses

This study shows that Foxp3-{Delta}E2 Tregs have impaired suppressive function, leading to enhanced CD8+ T cell responses during inflammation.

Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8+ T cells During Macrophage Activation Syndrome

The paper identifies a type I IFN-driven monocyte dysregulation and a MAS-associated CD8+ T cell population in macrophage activation syndrome using bulk and single-cell RNA sequencing.

Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function

This study shows that loss of FLII impairs CD8+ and regulatory T cell function by affecting trafficking and immune regulation.

The altered T cell landscape in Systemic Sclerosis patients is characterized by dysfunctional type 1 immunity.

This study identifies dysfunctional type 1 immunity in SSc patients through altered T cell subsets and reduced IFN-γ production.

Divergent effects of a Treg selective IL-2 mutein on Influenza-specific T cell responses

This study examines how a Treg-selective IL-2 mutein affects influenza-specific T cell responses, showing opposing effects based on administration timing.

T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts

The paper shows how different T cell types drive distinct transcriptional changes in skin cells during inflammation, linking these changes to diseases like psoriasis and scleroderma.

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

The paper identifies causal genetic variants in autoimmune diseases by combining allele-specific reporter assays with chromatin accessibility data, showing their impact on gene expression and T cell function.

Circulating CD4+ memory T cells give rise to a CD69+ resident memory T cell population in non-inflamed human skin

The paper shows circulating CD4+ memory T cells can generate CD4+CD69+ resident memory T cells in non-inflamed human skin without infection or inflammation.