Trazodone rescues dysregulated synaptic and mitochondrial nascent translatomes in prion neurodegeneration
Héctor Albert‐Gascó, Heather Smith, Beatriz Alvarez‐Castelao, Dean Swinden, Mark Halliday, Sudha Janaki‐Raman, Adrian J. Butcher, Giovanna R. Mallucci
This study shows trazodone restores synaptic and mitochondrial protein synthesis in prion-diseased mice, reversing neurodegeneration through translational modulation.
bioRxiv · Jun 5, 2023 · PreprintNeuroscience