Beatriz Alvarez‐Castelao

This paper introduces a multicopy MetRS* mouse line to enhance cell type-specific in vivo protein labeling, enabling sensitive detection of newly synthesized proteins in sparse cell populations.

This study identifies POMP as a stress-induced transcriptional regulator that buffers proteasome dysfunction through a non-canonical role in nucleolar RNA processing.

This study shows trazodone restores synaptic and mitochondrial protein synthesis in prion-diseased mice, reversing neurodegeneration through translational modulation.

The paper develops a method to profile subcellular transcriptomes of single neurons, revealing that GABAergic interneurons have localized mRNAs similar to excitatory neurons.

Proteasome inhibition leads to reduced neuronal protein synthesis through stabilization and enhanced translation of HRI kinase, which is constitutively active due to low neuronal heme levels.