Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.
Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos A. Gerencser, Judith Campisi, Denis Wirtz, Pei‐Hsun Wu, Birgit Schilling
This study identifies functionally distinct senescent cell subpopulations based on cell cycle status, showing G2-arrested cells secrete more IL-6 and are more sensitive to senolytic treatment.
Aging · Aug 7, 2025Peer-reviewedCell Biology