The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos A. Gerencser, Judith Campisi, Denis Wirtz, Pei‐Hsun Wu, Birgit Schilling

This study identifies functionally distinct senescent cell subpopulations based on cell cycle status, showing G2-arrested cells secrete more IL-6 and are more sensitive to senolytic treatment.

Aging · Aug 7, 2025Peer-reviewedCell Biology

Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

Kizito‐Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A. Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez‐Ramirez, Swati B. Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja N. Holtz, Claudio A. Hetz, , Lisa Ellerby

The paper performs proteomic analysis of Huntington's disease patient-derived medium spiny neurons, identifying altered lipid metabolism and lipid droplet accumulation as key findings.

Molecular & Cellular Proteomics · Mar 22, 2023Peer-reviewedNeuroscience