Exploring lipid nanoparticle design spaces using self-regulating microfluidic machines and multiplexed in vivo biodistribution
Josef Kehrein, Elena Reus, Caroline T. Holick, Sebastian Mummel, Ilayda Ates, Markus Hafke, Jonas Käsbach, Christine Weber, Tessa C. Lühmann, Stephanie Schubert, Jørgen Magnus, Florian A. Mann, Ulrich S. Schubert, Lorenz Meinel
This paper develops an automated microfluidic platform to optimize lipid nanoparticle formulations and evaluates their biodistribution in mice, finding that PEtOx-based LNPs show improved structural properties and bone marrow accumulation.
bioRxiv · Jun 8, 2026 · PreprintBioengineering