Infection of human organoids supports an intestinal niche for Chlamydia trachomatis
Pargev Hovhannisyan, Kathrin Stelzner, Markus Keicher, Kerstin Paprotka, Mastura Neyazi, Mindaugas Paužuolis, Waled Mohammed Ali, Karthika Rajeeve, Sina Bartfeld, Thomas Rudel
This study infects human intestinal organoids with Chlamydia trachomatis, showing resistance to apical infection and basolateral entry, and identifies Pgp3 as a key virulence factor.
PLoS Pathogens · Aug 22, 2024Peer-reviewedMicrobiology