Thomas Rudel

This study identifies sphingolipids, specifically sphingomyelin, as key molecules involved in DNA condensation and developmental regulation in Chlamydia trachomatis.

This paper develops a fluorometric assay combined with expansion microscopy to visualize sphingomyelin biosynthesis at nanoscale resolution in cells.

The paper introduces AIDE, a tool for minute-scale degradation of bacterial effectors in host cells, revealing dynamic roles of specific effectors in infection.

This study identifies CT181 as a Chlamydia trachomatis effector protein that binds Mcl-1 to prolong neutrophil survival, aiding bacterial persistence and pathogenesis.

This study shows that type IV pilus function is critical for Neisseria gonorrhoeae adherence to corneal epithelium models and that pilus retraction reduces bacterial attachment.

This study shows that Chlamydia trachomatis infection increases miR21, which reduces PTEN and activates PI3K signaling, promoting bacterial growth and tumor-like metabolism.

This study identifies the LutACB operon's role in Neisseria gonorrhoeae resistance to neutrophil-mediated oxidative stress by linking lactate utilization to sulfur metabolism.

This study shows that the Staphylococcus aureus NRPS AusA preferentially uses exogenous phenylalanine and tyrosine for aureusimine biosynthesis, while valine can come from both internal and external sources.

This study infects human intestinal organoids with Chlamydia trachomatis, showing resistance to apical infection and basolateral entry, and identifies Pgp3 as a key virulence factor.