DNA damage dependent hypomethylation regulates the pro-angiogenic LncRNA MEG9
Cristina Espinosa-Diez, RaeAnna Wilson, Rishima Mukherjee, Marlee Feltham, Clayton Hudson, Rebecca Ruhl, Sudarshan Anand
The paper shows DNA damage reduces DNMTs in endothelial cells, leading to increased MEG9 expression, which protects cells from DNA damage-induced death and promotes angiogenesis.
bioRxiv · Oct 14, 2018 · PreprintCell Biology