Cell-of-origin epigenome underlies SS18::SSX-mediated transformation
Lesley A. Hill, R. Wilder Scott, Lauren A. Martin, Martin Arostegui, George Davenport, Marcos Vemon, Jakob Hofvander, Xue Q. Wang, Jinxiu Li, Torsten O. Nielsen, Kevin B. Jones, Martin Hirst, T. Michael Underhill
This study identifies the cell-of-origin of synovial sarcoma as a rare fibroblastic population and shows that SS18::SSX induces an embryonic-like mesenchymal stem cell phenotype.
Nature Communications · Dec 2, 2025Peer-reviewedCancer Biology