Spatial single cell transcriptomic analysis of a novel DICER1 Syndrome GEMM informs the cellular origin and developmental hierarchy of associated sarcomas
Felix K. F. Kommoss, Joyce Yu Han Zhang, Branden J. Lynch…·David D. Huntsman
This study uses a mouse model to identify a fibroblastic origin for DICER1 sarcomas and shows their potential to differentiate into rhabdomyoblastic or anaplastic sarcomas.