Author

Mary Lou Biggs

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Bruce M. PsatyiD· 3 shared Alanna C. MorrisoniD· 2 shared Álvaro AlonsoiD· 2 shared Charlotte AnderssoniD· 2 shared Claudia LangenbergiD· 2 shared Dan E. ArkingiD· 2 shared Donna K. ArnettiD· 2 shared Eric BoerwinkleiD· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Bruce M. PsatyORCID

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Author profile →

4 papers

Recent·Most cited

Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits

Kenneth E. Westerman, Maura E. Walker, Sheila M. Gaynor, Jennifer Wessel, DANIEL A. DICORPO, Jiantao Ma, Álvaro Alonso, Stella W. Aslibekyan, Abigail S. Baldridge, Alain Gerald Bertoni, Mary Lou Biggs, Jennifer A. Brody, Yii-Der Ida Chen, Josée Dupuis, Mark O. Goodarzi, , Alisa Knodle Manning

The paper identifies a gene-diet interaction modifying the association between macronutrient intake and glycemic traits, highlighting challenges in detecting such interactions due to measurement error and sample size.

Diabetes · Feb 15, 2023Peer-reviewedGenetic & Genomic Medicine

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia‐Ling Kuo, Janice L. Atkins, Joshua Richard Lewis, ThuyVy Duong, Shengjun Hong, Mary Lou Biggs, Jian’an Luan, Chloé Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, , Luke C. Pilling

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

Nature Communications · Jan 28, 2021Peer-reviewedGenetic & Genomic Medicine

De novo mutations across 1,465 diverse genomes reveal novel mutational insights and reductions in the Amish founder population.

Michael D. Kessler, Douglas P. Loesch, James A. Perry, Nancy L. Heard‐Costa, Daniel Taliun, Brian E. Cade, Heming Wang, Michelle Daya, John P. Ziniti, Soma Datta, Juan Carlos Celedon, Manuel E. Soto-Quirós, Lydiana Ávila, Scott T. Weiss, Kathleen C. Barnes, , Mary Lou Biggs

The paper analyzes de novo mutations in 1,465 genomes to show similar mutation rates across ancestries but reduced rates in the Amish population, with environmental factors possibly influencing mutation rates.

Proceedings of the National Academy of Sciences · Jan 21, 2020Peer-reviewedGenetics

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

Sonia H Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadóttir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, , David J. Stott

This study conducts a large GWAS on heart failure, identifying 12 genetic loci with associations to CAD, atrial fibrillation, and reduced left ventricular function, and provides causal evidence for several risk factors.

bioRxiv · Jul 10, 2019 · PreprintGenetics