Chia‐Ling Kuo

The paper uses single-cell profiling to show CMV drives clonal expansion of GZMK CD8 and Th1 cells in humans.

The paper develops a proteomic signature (HPS) to predict healthspan, showing it predicts mortality and age-related diseases better than other biological age measures.

The paper develops a proteomic aging clock (PAC) that predicts all-cause mortality and disease outcomes in middle-aged and older adults using plasma protein data.

This paper combines pharmacogenetic variants and polygenic scores for patient characteristics to improve prediction of clinical outcomes in Calcium Channel Blocker treatment.

This study finds that CYP2C19 loss-of-function variants are associated with increased risk of ischemic stroke and MI in patients on long-term clopidogrel therapy in primary care.

The paper introduces the TWIST framework for causal inference in pharmacogenetics, showing how to combine different estimation strategies to improve robustness and efficiency in estimating genetically moderated treatment effects.

This study identifies genetic associations for two biological age measures, revealing distinct aging phenotypes linked to different pathways and APOE variants.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

The paper re-evaluates the association between ApoE e4e4 genotype and COVID-19 test positivity and mortality in the UK Biobank cohort, finding increased risks for both outcomes compared to e3e3 genotype.

The paper assesses the effects of ApoE e2 variants on aging-related outcomes using UK Biobank data, finding protective effects for e2e3 but not e2e2.

The paper investigates the association between ApoE e4 genotype and severe COVID-19 in the UK Biobank community cohort, finding a link with increased risk of severe outcomes.

This study identifies genetic variants associated with red blood cell distribution width (RDW) in 166,666 UK Biobank volunteers, linking RDW to aging-related pathways and health outcomes.