Toshiko Tanaka

DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging

The paper identifies DNA methylation variability and differential methylation regions associated with aging-related health decline and constructs an epigenetic biomarker that outperforms methylation-only biomarkers in predicting mortality.

SomaModules: a pathway enrichment approach tailored to SomaScan data

This paper introduces SomaModules, a pathway enrichment approach for SomaScan data, showing improved enrichment compared to original gene sets in Alzheimer's Disease and mitochondrial pathway analyses.

Variability of 7K and 11K SomaScan plasma proteomics assays

Across Baltimore Longitudinal Study of Aging replicates, fully normalized SomaScan 11K has median inter-plate coefficient of variation 5% (7K: 4.5%), intra-plate 3%, 7K inter-batch 8%.

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

This study identifies genetic signals associated with age at menarche, highlights genes involved in pubertal development, and links reproductive timing to later life disease risk.

Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

The paper identifies novel genetic loci associated with systolic blood pressure that interact with the DASH diet score through genome-wide interaction analysis.

Epigenetic signature of human immune aging: the GESTALT study.

The paper identifies age-associated DNA methylation sites in immune cells and links them to transcription factor motifs and histone modifications, suggesting adaptive responses to oxygen fluctuations in aging.

Large-scale Rare Variant Burden Testing in Parkinson's Disease Identifies Novel Associations with Genes Involved in Neuro-inflammation

Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies

This study finds that blood mitochondrial DNA copy number is consistently associated with personality traits and mediates the link between personality and mortality in two genetic cohorts.

Assessment of Variability in the Plasma 7k SomaScan Proteomics Assay

Using inter-plate duplicates from 102 donors, a self-contained normalization of the 7k SomaScan plasma assay yields median CV 4.5% across 7,288 human-protein SOMAmers.

Genome-wide analysis of Structural Variants in Parkinson's Disease using Short-Read Sequencing data

This study identifies 3,154 high-confidence structural variants in Parkinson's disease using short-read sequencing and validates some with long-read data, highlighting limitations of short-read methods.

An integrative analysis of clinical and epigenetic biomarkers of mortality

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

This paper introduces revTWMR, a method to determine causal relationships between gene expression and complex traits, finding that traits more strongly influence gene expression than vice versa.

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

Comparative analysis of epigenetic aging clocks from CpG characteristics to functional associations

This study compares 11 epigenetic aging clocks using DNA methylation data from human tissues and cells, finding differences in CpG characteristics, tissue specificity, and gene network associations.

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Discovering patterns of pleiotropy in genome-wide association studies

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.