Powassan Virus NS5 Antagonizes TYK2-Mediated Immune Signaling Pathways
Mary O'Mara, Melissa Molho, Andrew P. Kurland, Zachary Walter, Ségolène Gracias, Vincent Caval, Nolwenn Jouvenet, Jeffrey R. Johnson, Holly R. Ramage
This study identifies POWV NS5 as a central inhibitor of cytokine signaling by targeting TYK2 and suppressing multiple antiviral pathways.
bioRxiv · Sep 8, 2026 · PreprintMicrobiology