Jeffrey R. Johnson

The paper uses proteomic analysis and molecular dynamics simulations to uncover how ANKLE2 mutations disrupt protein interactions and phosphorylation, leading to microcephaly.

This study identifies USP7 as a gene that restricts neurotropic orthoflavivirus entry by controlling endosomal dynamics, with mutations in USP7 increasing susceptibility to ZIKV infection.

This study identifies POWV NS5 as a central inhibitor of cytokine signaling by targeting TYK2 and suppressing multiple antiviral pathways.

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

The paper introduces an inverse Transwell assay to study mucus barrier function against respiratory viruses and identifies MUC5AC's role in antiviral defense.

This study identifies HIV-1-induced SUMOylation of host RNA splicing factors, mediated by Vif, which regulates viral RNA splicing and infectivity.

This study identifies phosphoregulation of nuclear protein complexes by HIV-1 latency-reversing agents, revealing shared mechanisms across different LRAs.

The paper identifies glypican-1 (GPC1) as a novel modulator of HIV-1 infection, showing its upregulation by a kinase inhibitor enhances viral infection through TGF-β signaling.

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

This paper develops a split ALFA tag-nanobody system for protein localization and proximity proteomics in mycobacteria, demonstrating its utility in identifying protein complexes and localization patterns.

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

This study identifies CebN, a Chlamydia trachomatis effector that targets nucleoporins and Rae1 to disrupt STAT1 nuclear import, aiding bacterial survival.

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

The paper shows apoE4 increases VASP phosphorylation, disrupting actin interactions and affecting neurite outgrowth in Neuro-2a cells.

This study identifies TRIM1 as an E3 ligase that ubiquitinates LRRK2, regulating its localization, degradation, and toxicity in Parkinson's Disease.

The paper identifies 2747 SUMO modification sites in budding yeast meiosis, revealing SUMO's role in chromosome organization and recombination.

The paper investigates how acetylation and phosphorylation of RNA polymerase II CTD interact through RPRD proteins, showing acetylation regulates phosphorylation and vice versa.

The paper uses proteomic analysis to identify TAX1BP1 as a mediator of autophagy targeting M. tuberculosis during macrophage infection.

The paper identifies BAF complex subunit dynamics during cardiac differentiation, showing how BAF60c and BAF170 regulate gene expression programs in cardiac precursors and cardiomyocytes.

The paper identifies Mtb-human protein-protein interactions, showing LpqN antagonizes CBL, a host ubiquitin ligase that balances anti-viral and anti-bacterial responses in macrophages.

The paper analyzes the phosphoproteome of Xenopus laevis, identifies conserved phosphorylation sites, and links them to structural flexibility and functional regulation.