Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries
Yulun Wu, Hamsa Vardini Senthil Kumar, Sai Harsha Bhamidipati, Haibo Yu, Pihu Mehrotra, Pedro Lei, Arundhati Das, Patrick Saari, Maryam Elsayed, Linzhang Huang, Stelios T. Andreadis
This study identifies GPR81 loss as a driver of vascular senescence and shows that its activation can reverse age-related metabolic dysfunction in arteries.
bioRxiv · Sep 25, 2026 · PreprintBioengineering