Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes
Yuta Yanagihara, Masatomo Takahashi, Yoshihiro Izumi, Tomofumi Kinoshita, Masaki Takao, Takeshi Bamba, Yuuki Imai
This study shows that Dnmt1 regulates bone length by controlling energy metabolism in chondrocytes through DNA methylation and gene expression changes.
Nature Communications · Nov 4, 2025Peer-reviewedDevelopmental Biology