Yoshihiro Izumi

The paper develops MassBank Human, a curated metabolomics resource that improves structural annotation of the human metabolome, doubling coverage in colorectal cancer cells and identifying acetylated polyamines as metabolic markers.

This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.

This study shows that Dnmt1 regulates bone length by controlling energy metabolism in chondrocytes through DNA methylation and gene expression changes.

This study uses lipidomics and proteomics to analyze lipoprotein changes in coronary atherosclerosis, finding ceramide molecules are significantly associated with early stage progression.

This study shows that cholesterol sulfate prevents maternal-fetal immune conflict by modulating immune reactivity in pregnant mice and humans.

The paper examines how obesity disrupts the temporally ordered metabolic network in the liver during starvation, revealing structural robustness but temporal vulnerability.

The paper compares metabolic dysregulation in obese mice during feeding and fasting using multi-omics data, revealing opposite metabolic shifts linked to obesity.

This study shows that sustained NFκB activity promotes cellular senescence by altering purine metabolism and epigenetic regulation through IκB and A20 dysfunction.

The paper develops an LC/MS/MS method to measure over 140 bioactive lipids in human plasma, revealing sex and circadian differences.