Estradiol Modulates Cytotoxic Responses to Topoisomerase II Targeting Agents in Estrogen Receptor Positive Breast Cancer Cells
Nisha Thomas, Nai-Yun Sun, Mathew Cherian
This study shows estradiol enhances the cytotoxicity of topoisomerase II poisons in ER+ breast cancer cells, suggesting E2-induced cell death relies on TOP2-mediated DNA breaks.
bioRxiv · Oct 20, 2026 · PreprintCancer Biology