Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis
Austin Tedman, Muskan Goel, Sohan Shah, Mathew K. Howard, Laura M. Chamness, Antonio Bonifasi, Ismalia Adams, Jacklyn M. Gallagher, Wesley D. Penn, Katarina Nemec, Eli Fritz McDonald, Brianna N. Corman, Joseph Paul Robinson, Carol Beth Post, Patricia L. Clark, , Jonathan P. Schlebach
The paper introduces a platform to characterize GPCR expression and uses machine learning to identify structural features affecting their biosynthesis.
bioRxiv · Sep 19, 2025 · PreprintBiochemistry